Accuracy and feasibility of different diagnostic criteria of sepsis in intensive care unit
Jiang Lilei
Zhu Fengxue
Li Shu
Zhao Xiujuan
Xue Haiyan
Guo Fuzheng
Abstract：Objective To assess the predictive values of the Sepsis 1.0 and Sepsis 3.0 diagnostic criteria for prognosis and in-hospital mortality of sepsis in intensive care unit(ICU).Methods Clinical data of 413 patients admitted to ICU of surgery,emergency and respiratory departments of Peking University People's Hospital from January to August 2017 were studied according to Sepsis 1.0 and 3.0 diagnostic criteria.Predictive values of the two criteria for in-hospital mortality were analyzed by receiver operating characteristic (ROC) curve.Prognostic indicators such as Sequential Organ Failure Assessment (SOFA),systemic inflammatory response syndrome (SIRS),mechanical ventilation and age were analyzed.Results Respectively 169(40.9％) and 151 (36.6％)sepsis patients were confirmed by Sepsis 1.0 and 3.0 criteria.There were significant differences of the prognositic indicators between them and sepsis patients according with Sepsis 3.0 had worse prognosis(P ＜ 0.01).Area under ROC curve of SOFA score predicting in-hospital mortality was greater than that of SIRS (0.654 vs 0.508) (P ＜0.05).The prognosis was poorer with the increase of SOFA score (P ＜ 0.05).There were also significant differences of the prognosis between patients of different ages and whether they were mechanically ventilated(P ＜0.05).Conclusions Sepsis patients diagnosed by Sepsis 3.0 show worse prognosis than those who are diagnosed by Sepsis 1.0.Sepsis 3.0 shows a high prediction efficiency for in-hospital mortality.High SOFA score,advanced age and mechanical ventilation indicate poor prognosis.
Keywords：SepsisIntensive care unitSystemic inflammatory response syndromeSequential organ failure assessmentPrognosis assessment
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 82-86 )