Effect of stellate ganglion block with 1％ lidocaine on circulatory function and immune function in patients undergoing elective laparoscopic cholecystectomy
Zi Congna
Fan Juan
Ma Xian
Li Fulong
Abstract：Objective To investigate the effect of stellate ganglion block(SGB) with 1％ lidocaine before anesthesia induction on circulatory function and immune function in patients undergoing elective laparoscopic cholecystectomy(LC).Methods Sixty patients undergoing elective LC from March to December 2016 in the First Hospital Affiliated of Hebei North University were randomly divided into observation group and control group,with 30 cases in each group.The control group was injected 10 ml 0.9％ sodium chloride while the observation group was injected 10 ml 1％ lidocaine at the root of right C6 transverse process under the guidance of ultrasound 30 min before anesthesia induction.Circulatory function indexes were monitored before SGB(T0),during tracheal intubation (T1),5 min after pneumoperitoneum(T2),at the end of pneumoperitoneum (T3),5 min after extubation (T4),6 h after operation(T5) and 8 h after operation(T6).Immune function indexes were tested at T0,T5,the 1st day after operation(T7) and the 3rd day after operation(T8).Visual Analogue Scale for pain was assessed at different time points after operation.Results Heart rate and mean arterial pressure at T2-T5 and end-tidal carbon dioxide partial pressure at T2 and T3 in the observation group were significantly lower than those in the control group (all P ＜ 0.05).CD3+,CD4+ and CD4+/CD8+ in the observation group at T5 were significantly higher than those in the control group[(60 ±7)％ vs (56 ±7)％,(37 ±5)％ vs (35 ±4)％,(1.85 ±0.40) vs (1.63 ±0.35)];CD4+ and CD4+/CD8+ at T7 in the observation group were significantly higher than those in the control group [(39 ± 4)％ vs (36 ± 5) ％,(1.78 ± 0.29) vs (1.53 ± 0.20)] (all P ＜ 0.05).VAS scores at T5 and T7 in the observation group were significantly lower than those in the control group[(2.6 ±0.6) vs (3.0 ±0.6),(1.8 ±0.6) vs (2.4 ±0.4)](t =2.582,4.557,both P ＜ 0.05).Conclusion SGB with 1％ lidocaine shows a good postoperative analgesia effect on patients undergoing LC and little effect on the circulatory function and immune system.
Keywords：Laparoscopic cholecystectomyLidocaineStellate ganglion block
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 69-72 )