Relation between expression of hypoxia inducible factor-1Ω and clinical prognosis in patients with non-small cell lung cancer
Jiang Youguo
Deng Sanming
Luo Jian
Liu Juntao
Pan Liangliang
Wang Taoyuan
Abstract：Objective To investigate the expression of hypoxia inducible factor-1α(HIF-1 Ω) in non-small cell lung cancer and the impact on prognosis.Methods From January 2015 to January 2017,120 patients with newly diagnosed non-small cell lung cancer in the Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces were enrolled.Expression of HIF-1α in lung biopsy tissue was tested by immunohistochemistry.Prognosis of patients was observed in 1 year after discharge.The relation between HIF-1α expression and metastasis/recurrence or death was analyzed.Results Positive rates of vascular endothelial growth factor(VEGF) and VEGF receptor 2 (VEGFR2) in HIF-1α positive patients were significantly higher than those in HIF-1α negative patients [77.3％ (68/88) vs 65.6％ (21/32),75.0％ (66/88) vs 62.5％ (20/32)] (P ＜ 0.05).During 1-year follow-up,17 patients had metastasis or recurrence;the rate of metastasis/recurrence in HIF-1α positive patients was significantly higher than that in HIF-1α negative patients [17.0％ (15/88) vs 6.2％ (2/32)] (P ＜ 0.05).There were 6 deaths,including 4 cases of HIF-1α positive and 2 cases of HIF-1α negative.Logistic regression analysis suggested that HIF-1α,VEGF and VEGFR2 positive expression were risk factors of metastasis/recurrence and death in non-small cell lung cancer patients (odds ratio ＞ 1,P ＜ 0.05).Conclusion HIF-1α,VEGF and VEGFR2 positive expression are risk factors of metastasis,recurrence and death in non-small cell lung cancer atients.
Keywords：Non-small cell lung cancerHypoxia inducible factor-1αVascular endothelial growth factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 58-61 )