Effect of biological valve replacement combined with torasemide on heart valve disease and levels of brain natriuretic peptide and lipoprotein-associated phospholipase A2
Zhou Zifan
Wang Longfei
Dong Songpo
Pan Xudong
Liu Ningning
Xu Shangdong
Sun Lizhong
Abstract：Objective To explore the effect of biological valve replacement combined with torasemide on patients with heart valve disease and the levels of brain natriuretic peptide (BNP) and lipoprotein-associated phospholipase A2(Lp-PLA2).Methods From May 2014 to May 2017,118 patients with heart valve disease admitted to Beijing Anzhen Hospital,Capital Medical University were randomly divided into observation group and control group,with 59 cases in each group.The control group was treated with biological valve replacement.The observation group had biological valve replacement combined with intravenous administration of torasemide.Clinical efficiency,heart function,serum levels of inflammatory factors,BNP and Lp-PLA2 Were analyzed.Results Therapeutic effective rate in the observation group was significantly higher than that in the control group [96.6％ (57/59) vs 78.0％ (46/59)] (P ＜ 0.05).After treatment,cardiac output,cardiac index and left ventricular ejection fraction were improved compared to those before treatment in both groups;these indicators in the observation group were significantly higher than those in the control group [(6.18 ± 0.83) L/min vs (5.23 ±0.78)L/min,(3.28±0.16)L/(min · m2) vs (2.97 ±0.14)L/(min · m2),(55.2 ±3.8)％ vs (42.2±3.2) ％];levels of tumor necrosis factor-α,interleukin-1β and interleukin-6 significantly decreased;the levels in the observation group were significantly lower than those in the control group [(9.3 ± 1.3) pmol/L vs (14.0 ±2.3)pmol/L,(0.16 ± 0.07) μg/L vs (0.23 ± 0.08) μg/L,(92±8)ng/L vs (109±9)ng/L];BNP level increased and Lp-PLA2 level decreased compared to those before treatment;BNP level in the observation group was significantly higher and Lp-PLA2 level was significantly lower than those in the control group [(837 ± 38) ng/L vs (538 ± 32) ng/L,(141 ± 10) μg/L vs (166 ± 10) μg/L] (all P ＜ 0.05).Conclusion Biological valve replacement combined with torasemide treating heart valve disease can significantly improve heart function,reduce inflammatory reaction,increase the level of serum BNP and decrease serum Lp-PLA2.
Keywords：Heart valve diseaseBiological valve replacementTorasemideBrain natriuretic peptideLipoprotein-associated phospholipase A2
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 45-49 )