Diagnostic value of combined detection of superoxide dismutase, homocysteine and high sensitive C-reactive protein in coronary atherosclerotic heart disease
Qin Wei
Wang Qing
Li Li
Abstract：Objective To investigate the value of combined detection of serum superoxide dismutase (SOD),homocysteine (Hcy) and high sensitive C-reactive protein (hs-CRP) in the diagnosis of coronary atherosclerotic heart disease (CHD).Methods From February 2017 to March 2018,105 CHD patients and 90 healthy people were enrolled in Feicheng People's Hospital.Levels of serum SOD,Hcy and hs-CRP were tested and their diagnostic values were analyzed.Results Levels of serum Hcy and hs-CRP in CHD patients were significantly higher and SOD was significantly lower than those in healthy people [(21.2 ± 4.1)kU/L vs (8.4 ±1.8)kU/L,(21.5 ±4.5)μmol/L vs (2.2 ± 1.5) μmol/L,(97 ± 12) mg/L vs (110 ± 11)mg/L] (P ＜0.01).Receiver operating characteristic curve showed that the areas under curve(95 ％ confidence interval) of SOD,Hcy and hs-CRP in diagnosing coronary heart disease were 0.631 (0.553-0.709),0.705 (0.631-0.780),0.809 (0.751-0.867);the sensitivities were 51.4％,59.0％,56.2％;the specificities were 82.4％,91.6％,92.6％;Yoden indexes were 33.8,50.6,48.8,respectively;combined detection of the 3 indicators showed the highest sensitivity(74.8％),specificity (96.2％),area under the curve (0.901) and Youden index (71.0).Conclusion Combined detection of SOD,Hcy and hs-CRP can improve the diagnostic accuracy for CHD.
Keywords：Coronary heart diseaseSuperoxide dismutaseHigh sensitive C-reactive proteinHomocysteine
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 37-40 )