Relation between circulating soluble ST2 concentration related gene polymorphism and aortic aneurysm
Wang Yuan
Jiang Wenxi
Wang Xue
Wang Luya
Ke Bingbing
Du Jie
Abstract：Objective To investigate the relation between circulating soluble ST2 concentration related gene polymorphism and aortic aneurysm.Methods A total of 331 patients with aortic aneurysm admitted to Beijing Anzhen Hospital,Capital Medical University from January 2014 to December 2016 were selected as observation group.Twenty-seven significant single nucleotide polymorphisms (SNPs) of ST2 concentration related genes reported in published literatures were detected.Detection process included whole genomic DNA extraction,polymerase chain reaction amplification,matrix-assisted laser desorption ionization time-of-flight mass spectrometry and genotyping analysis by TYPER 4.0 software.Genetic information of 208 Chinese people in the 1 000 Genomes Project were control group.Genotypes and allele distributions were analyzed between groups.Relation between allele frequencies of certain genes and risk of aortic aneurysm was analyzed by Logistic regression.Results Minor allele frequencies of 6 SNPs (rs12987900,rs12997225,rs13015695,rs11693697,rs13029918 and rs11465699) were less than 0.01 and they were excluded.Remaining 21 SNPs were tested to met the Hardy-Weinberg equilibrium (all P ＞0.001).There were significant differences of rs1420103,rs17027037,rs17027230 and rs12463588 genotype distribution between groups (P ＜ 0.05).Distribution of rs1420103 showed the most significant difference between groups.Genotype rs1420103 was detected in 329 patients in the observation group;frequencies of A and C alleles were 346(52.6％) and 312(47.4％).Frequencies of A and C alleles were 183(44.0％) and 233(56.0％) in the control group.Frequency of rs14020103 A allele in the observation group was higher than that in the control group;rs1420103 genotype was correlated with aortic aneurysm(odds ratio =1.402,95％ confidence interval:1.096-1.793,P =0.007).Conclusion Allele A of rs1420103 gene is a risk factor of aortic aneurysm.
Keywords：Aortic aneurysmST2Single nucleotide polymorphism
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 33-37 )