Application of echocardiographic right ventricular function indexes and brain natriuretic peptide in clinical diagnosis of pediatric heart disease complicated with pulmonary artery hypertension
Zheng Zhi
Tang Jingjing
Peng Yuan
Abstract：Objective To analyze the diagnostic values of echocardiographic right ventricular function indexes and brain natriuretic peptide in children with heart disease complicated with pulmonary artery hypertension.Methods From February 2017 to March 2018,110 children with heart disease complicated with pulmonary artery hypertension and 40 healthy children were enrolled in Sichuan Provincial People's Hospital.According to the severity of pulmonary hypertension,110 heart disease children were divided into mild group (n =49),moderate group(n =39) and severe group (n =22);40 healthy children were control group.Right ventricular function indexes of echocardiography and brain natriuretic peptide level were analyzed.Results Tei index in the severegroup was higher than that in the control group,mild group and moderate group[(0.46 ±0.14) vs (0.31 ±0.05),(0.32 ± 0.06),(0.33 ± 0.08)] (P ＜ 0.05);there were no significant difference between the control,mild and moderate groups (P ＞ 0.05).Pulmonary to systemic blood flow ratio(Qp/Qs) and level of serum brain natriuretic peptide showed significant rising trends among the control group,mild group,moderated group and severe group [(1.6 ±0.3),(2.4 ±0.4),(3.0 ±0.4),(3.4 ±0.4);(33 ±4),(59 ± 8),(104 ± 13),(147 ± 18)μg/L];fractional area change (FAC) showed a declining trend among the four groups [(53 ± 5) ％,(45 ± 4) ％,(36 ±6) ％,(30 ± 6) ％] (all P ＜ 0.05).Conclusions Echocardiographic right ventricular function indexes and brain natriuretic peptide level in children with heart disease combined with pulmonary hypertension show significant differences compared to those in healthy children,which may provide references for the clinical diagnosis.Brain natriuretic peptide level and Qp/Qs increase and FAC decreases with the severity of pulmonary hypertension.
Keywords：Pediatric heart diseasePulmonary artery hypertensionUltrasonographyRight cardiac functionBrain natriuretic peptide
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 29-32 )