Clinical effects of Xinmailong injection and lyophilized recombinant human brain natriuretic peptide on ischemic heart failure evaluated by non-invasive hemodynamic monitoring
Lin Mingkuan
Liu Hao
Liang Liudan
Zhang Hua
Ji Xiaoli
Yan Jun
Zhang Mingzhe
Wei Jing
Abstract：Objective To investigate the clinical effects of Xinmailong injection and lyophilized recombinant human brain natriuretic peptide(rhBNP) on ischemic heart failure evaluated by non-invasive hemodynamic monitoring.Methods From February 2015 to February 2017,96 patients with ischemic heart failure in Sanya People's Hospital were randomly divided into control group and observation group,with 48 cases in each group.On the basis of routine medication,the control group was treated with rhBNP and the observation group was treated with Xinmailong injection for 5 days.Non-invasive cardiac function indicators,N-terminal brain natriuretic peptide precursor (NT-proBNP),urine volume,serum uric acid,serum sodium and adverse reactions were analyzed.Results During treatment,left ventricular ejection fraction on the 5th day,cardiac output on the 4th and 5thdays,cardiac index on the 5th day in observation group were significantly higher than those in control group [(0.52±0.08)％ vs (0.46±0.16)％,(3.24 ±0.44)L/min vs (2.72 ±0.38)L/min,(3.36 ±0.45)L/min vs (2.68 ± 0.34) L/min,(2.8 ± 0.6) L/(min · m2) vs (2.2 ± 0.5) L/(min · m2)];systemic vascular resistance and systemic vascular resistance index on the 4th and 5th days in observation group were significantly higher than those in control group [(1 652 ± 325) DS/crn5 vs (1 546 ± 320) DS/cm5,(1 654 ± 324) DS/cm5 vs (1 510 ± 310) DS/cm5,(2 796 ±421)DS/(min2 · m5) vs (2052 ±418)DS/(min2 · m5),(2624 ±419)DS/(min2 · ms) vs (2045 ±404) DS/(min2 · m5)] (all P ＜ 0.05).After treatment,NT-proBNP level and serum uric acid level in observation group were significantly lower and urine volume was higher than those in control group(all P ＜0.05).No adverse reactions such as malignant arrhythmia,deterioration of heart failure and acute coronary syndrome occurred during treatment.Conclusion Xinmailong injection can significantly improve cardiac ejection,cardiac output and cardiac index,while lyophilized recombinant human brain natriuretic peptide can significantly reduce peripheral vascular resistance in the treatment of ischemic heart failure.
Keywords：Ischemic heart failureLyophilized recombinant human brain natriuretic peptideXinmailong injectionCardiac functionNon-invasive cardiac output
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 18-21 )