Correlation between plasma lipoprotein (a) and acute coronary syndrome
Chen Weijun
Dong Qian
Chen Yongfu
Wu Qiming
Abstract：Objective To investigate the correlation between plasma lipoprotein (a) [Lp (a)] and acute coronary syndrome(ACS).Methods Clinical data of 240 ACS patients (observation group) and 120 patients with main coronary artery stenosis ＜ 50％ (control group) in Beijing Ditan Hospital,Capital Medical University between May 2015 and October 2016 were retrospectively analyzed.Sex,age,body mass index,smoking,hypertension,diabetes,dyslipidemia and blood lipids were recorded.Risk factors of ACS were analyzed by single factor and multivariate Logistic regression.Results Ratios of type 2 diabetes,dyslipidemia,elevated Lp (a) level [≥ 300 mg/L] and levels of total cholesterol,low-density lipoprotein cholesterol (LDL-C),apolipoprotein (B) in observation group were significantly higher than those in control group;levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (A) in observation group were significantly lower than those in control group (all P ＜0.05).Multivariate Logistic regression showed that smoking,type 2 diabetes,LDL-C and Lp (a) ≥300 mg/Lwere independent risk factors of ACS (odds ratio =2.01,3.11,2.71,3.70;95％ confidence interval:1.13-3.58,1.70-5.69,1.88-3.91,1.99-6.90;P ＜ 0.05);HDL-C was a protective factor of ACS(odds ratio =0.17;95％ confidence interval:0.06-0.47;P ＜ 0.05).Conclusion Lp (a) is an independent risk factor of ACS;serum Lp(a) ≥300 mg/L significantly increases the risk of ACS.
Keywords：Acute coronary syndromeLipoprotein(a)Independent risk factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 15-17 )