Efficacy and safety of lisinopril hydrochlorothiazide tablets in elderly patients with mild-to-moderate essential hypertension: a multi-center clinical observation
Tan Xiaohong
Song Li
Yan Hongbing
Zhao Hanjun
Abstract：Objective To explore the efficacy and safety of lisinopril hydrochlorothiazide tablets in the treatment of mild-to-moderate essential hypertension in elderly patients.Methods Between June 2015 and August 2016,elderly outpatients with grade 1 or 2 essential hypertension were enrolled from 16 secondary or tertiary hospitals in China.All subjects had taken lisinopril hydrochlorothiazide tablets for at least 8 weeks.Fluctuations and standard rate of blood pressure and adverse reactions were analyzed via face-to-face questionnaire survey and medical record data review.Results A total of 348 patients were analyzed,including 161 males (46.3％),187 females (53.7％),44 patients with grade 1 hypertension(12.6％) and 304 patients with grade 2 hypertension (87.4％).Compared with baselines,the mean systolic blood pressure and diastolic blood pressure decreased by (25 ± 10) and (12 ± 6)mmHg respectively 4 weeks after medication.After 8 weeks of treatment,the mean declines of systolic and diastolic blood pressure were (30 ±9) and (15 ±6)mmHg respectively,which were significantly higher than those 4 weeks after treatment.The overall blood pressure compliance rate was 70.1％ (244/348) at 4 weeks and 97.1％ (338/348) at 8 weeks after treatment (P ＜ 0.001).Common adverse reactions were dry cough(25 cases,7.2％),dizziness(3 cases,0.9％) and headache(2 cases,0.6％).Symptomatic hypotension was not reported.Conclusion Lisinopril hydrochlorothiazide tablets show high safety and efficacy in the treatment of mild-to-moderate essential hypertension in the elderly.
Keywords：Mild-to-moderate essential hypertensionLisinopril hydrochlorothiazide tabletsMulti-center study
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 6-9 )