Risk factors associated with polypharmacy and anticoagulant therapy among elderly patients with non-valvular atrial fibrillation
Li Mengmeng
Liu Jiapeng
Li Jingye
Lu Shangxin
Xia Shijun
Chang Sanshuai
Guo Xueyuan
Wang Wei
Du Xin
Dong Jianzeng
Ma Changsheng
Abstract：Objective To investigate the influence factors of polypharmacy and its effect on anticoagulant therapy among elderly patients with non-valvular atrial fibrillation.Methods A cross-sectional analysis was performed among 500 patients who were 65 years or older with non-valvular atrial fibrillation from the China Atrial Fibrillation Registry.Demographic data,comorbidities and concomitant medication regimens were collected.Polypharmacy was defined as no less than 5 kinds of long-term prescribed drugs.Risk factors of polypharmacy and anticoagulant therapy were analyzed using multivariate Logistic regression.Results There were 247 cases in the polypharmacy group and 253 cases in the non-polypharmacy group.Polypharmacy was found to be independently associated with female gender,hypertension,diabetes,coronary heart disease and hyperlipidemia(odds ratio =1.64,2.17,2.81,2.98,1.59;95％ confidence interval:1.10-2.43,1.36-3.47,1.81-4.37,1.90-4.67,1.07-2.37;all P ＜ 0.05).Polypharmacy was not an indicator of anticoagulant use (P =0.10).Conclusions Polypharmacy is a major burden on the management of atrial fibrillation in the elderly.Female gender and many comorbidities are risk factors of polypharmacy.Polypharmacy does not increase the use of anticoagulants.
Keywords：Atrial fibrillationPolypharmacyAnticoagulants
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )