Clinical effect of deep thalamic stimulation on myoclonus dystonia syndrome
Zhang Wenjie
Li Jiping
Abstract：Objective To explore the clinical effect of thalamic deep brain stimulation(DBS) on myoclonus dystonia syndrome(MDS).Methods From January 2011 to April 2017,4 male patients with MDS who underwent Vim-DBS surgery at Xuanwu Hospital,Capital Medical University were retrospectively analyzed.The operation included two phases;the first phase was intracranial electrode implantation;the second phase was pulse generator implantation.Fall risk was assessed by Johns Hopkins Fall Risk Assessment Tool(JHFRAT).Activity of daily living was assessed by Barthel index.Myoclonia severity was assessed by Unified Myoclonus Rating Scale (UMRS).Movement disorder and functional disorder of dystonia were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS).Results Among the 4 patients,preoperative Barthel index was 40-70;the mean score was 55 with a moderate life dependence.Preoperative JHFRAT score was 8-30;the mean score was 16,indicating a high fall risk.The symptoms were alleviated after the first phase operation;no severe complication was observed after the second phase operation.At discharge,the myoclonia score,the movement and functional disorder scores were reduced;the mean score of Barthel index was 92.Conclusion Thalamic DBS has a good therapeutic effect on MDS.
Keywords：Myoclonus dystonia syndromeDeep brain stimulationRisk evaluation
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1674-1677 )