Effect and safety of oxiracetam combined with hyperbaric oxygen treatment on cognitive impairment after cerebral infarction

Wang Miaomiao; Li Jinjun; Wang Li; Jiang Fangkuang; Song Xianghong

doi:10.3760/j.issn.1673-4777.2018.11.016

Abstract：Objective To analyze the therapeutic effect and safety of oxiracetam combined with hyperbaric oxygen treatment on cognitive impairment after cerebral infarction.Methods A total of 100 patients with post-cerebral infarction cognitive impairment were enrolled from November 2015 to August 2016 in Shanghai MCC Hospital.They were randomly divided into control group and observation group,with 50 cases in each group.The control group took oxiracetam capsules.The observation group was treated with oxiracetam capsules combined with hyperbaric oxygen therapy.Mini-mental State Examination (MMSE),Montreal Cognitive Assessment (MoCA),Barthel index were assessed and levels of serum homocysteine(Hcy),C-reactive protein(CRP) and D-dimer were tested before and after treatment.Adverse reactions were observed during treatment.Results There were no significant differences of MMSE score,MoCA score,Barthel index,serum levels of Hcy,CRP and D-dimer between groups before treatment (P ＞ 0.05).After treatment,MMSE score,MoCA score and Barthel index significantly increased and the scores in observation group were significantly higher than those in control group [(25.3±1.7) vs (23.2±1.8),(24.0±1.7) vs (23.0±1.7),(59±6) vs (54±7)] (P＜0.01).After treatment,levels of serum Hcy,CRP and D-dimer significantly decreased;the levels in observation group were significantly lower than those in control group [(22 ± 3) μmol/L vs (25 ± 3) μmoL/L,(8 ± 3) mg/L vs (10 ± 3) mg/L,(1.2 ± 0.6) mg/L vs (1.7 ± 0.6) mg/L] (P ＜ 0.01).Incidence of adverse reactions showed no significant difference between groups(P =0.153).Conclusion Oxiracetam combined with hyperbaric oxygen treatment can effectively improve cognitive function and activity of living in cerebral infarction patients with cognitive impairment.