Efficacy and safety of Tianmasu injection in treatment of acute cerebral infarction: a meta analysis
Zhou Benhong
Chen Peng
Luo Yi
Abstract：Objective To evaluate the efficacy and safety of Tianmasu injection in the treatment of acute cerebral infarction.Methods Randomized controlled trials (RCTs) of Tianmasu injection treating acute cerebral infarction published before November 2017 were retrieved from PubMed,Web of Science,Institute for Scientific Information,Cochrane,Embase,China National Knowledge Infrastructure,Wanfang Data,Chinese Sci-tech Periodical Full-text Database and Chinese Biomedical Database.Cochrane risk assessment tool was used for quality assessment of RCTs.RevMan 5.3 software was used for meta analysis.Results Twelve RCTs with 1 062 patients were included.Meta analysis showed that the combined use of Tianmasu injection and western medicine treating acute cerebral infarction can improve the total effective rate (odds ratio =1.22,95％ confidence interval:1.05-1.41,P =0.008) and reduce neurologic injury (mean difference =-1.86,95％ confidence interval:-2.40 to-1.33,P ＜0.000 01);it can also improve the activity of daily living,improve hemorheology and reduce blood lipid level with few adverse reactions.Conclusion Tianmasu injection combined with western medicine has good effectiveness and safety in the treatment of cerebral infarction.
Keywords：Acute cerebral infarctionTianmasu injectionSafetyMeta analysis
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1655-1660 )