Effect of paclitaxel plus cisplatin chemotherapy combined with low molecular weight heparin sodium on elderly patients with non-small cell lung cancer

Chen Xiuyan; Hua Yanyan; Li Jie

doi:10.3760/j.issn.1673-4777.2018.11.014

Abstract：Objective To explore the effect of paclitaxel plus cisplatin(TP) chemotherapy combined with low molecular weight heparin sodium on elderly patients with non-small cell lung cancer.Methods A total of 120 elderly patients with non-small cell lung cancer were enrolled from April 2014 to December 2017 in Yangzhou Friendship Hospital and Affiliated Hospital of Jiangnan University.They were randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with TP chemotherapy;the observation group was treated with TP chemotherapy and low molecular weight heparin.After 4 courses of treatment (1 course was 3 weeks),clinical efficacy,tumor markers,D-dimer,quality of life and adverse reactions were analyzed.Results The total remission rate in the observation group was significantly higher than that in the control group[93.3％ (56/60) vs 83.3％ (50/60)] (P =0.032).After treatment,carcinoembryonic antigen,cancer antigen 125,cytokeratin fragment antigen 21-1 and D-dimer were significantly lower than those before treatment;the levels in the observation group were significantly lower than those in the control group(P ＜0.05).After treatment,the score of life quality in the observation group was significantly improved compared to that in the control group (P ＜ 0.05).Incidence of adverse reactions in the observation group was significantly lower than that in the control group [6.7％ (4/60) vs 25.0％ (15/60)] (P ＜ 0.05).Conclusion TP chemotherapy combined with low molecular weight heparin treating elderly patients with non-small cell lung cancer can effectively improve the efficacy,lower serum levels of tumor markers and D-dimer,improve quality of life and reduce adverse reactions.