Incidence of acute kidney injury and risk factors of prognosis in patients after heart multiple valve replacement
Yang Yanli
Ma Jun
Abstract：Objective To investigate the incidence of acute kidney injury (AKI) and the risk factors of prognosis in patients after multiple valve replacement.Methods A total of 1 140 patients who underwent multiple valve replacement in Beijing Anzhen Hospital,Capital Medical University from July 2013 to May 2014 were included.Perioperative records and follow-up data were analyzed.The main end-point was death.The secondary end-point was AKI.Relation between AKI and postoperative outcome was analyzed by Kaplan-Meier test and Log-Rank test.Risk factors of death were analyzed by multivariate Cox regression.Results Incidence of AKI in 1 140 patients was 24.4％ (n =278).All patients were followed up for (10 ±3)months and the death rate was 3.0％ (n =34).Death rate in AKI patients was significantly higher than that in non-AKI patients[5.8％ (16/278) vs 2.1％ (18/862)] (P =0.002).Cox regression analysis showed that the death rate in AKI patients was nearly doubled compared to that in non-AKI patients(relative risk =1.910,95％ confidence interval:1.010-3.160,P =0.003).Coronary heart disease,prolonged aortic clamp,plasma infusion and prolonged postoperative mechanical ventilation were also independent risk factors of death in patients after multiple valve replacement(all P ＜ 0.05).Conclusion Patients with multiple valve replacement have a high incidence of postoperative AKI,which is an independent risk factor of death.
Keywords：Multiple valve replacementAcute kidney injuryPrognosisRisk factor
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1631-1633 )