Relation between atherosclerotic cardiovascular disease and H-type hypertension

Zhang Yu; Ma Liangliang; Zhang Haiyin

doi:10.3760/j.issn.1673-4777.2018.11.006

Abstract：Objective To analyze the relation between atherosclerotic cardiovascular disease (ASCVD) and H-type hypertension.Methods Clinical data of 260 ASCVD patients who were treated in the First Hospital of Shijiazhuang from March 2015 to August 2017 were retrospectively analyzed.According to the results of percutaneous coronary angiography,the patients were divided into observation group (stenosis ≥ 50％,n =192) and control group(stenosis ＜ 50％,n =68).Basic medical records,blood lipid,Hcy and ambulatory blood pressure were analyzed.The relation among ASCVD,H-type hypertension and Hcy level was analyzed by Logistic regression.Results Age,H-type hypertension ratio[93.2％ (179/192) vs 45.6％ (31/68)],non-dipper and anti-dipper blood pressure ratio [65.6％ (126/192) vs 17.6％ (12/68)],smoking history ratio,diabetes history ratio,triglyceride level,Hcy level[(24 ± 12)pμ mol/L vs (16 ±8)μmol/L] in the observation group were significantly higher than those in the control group (P ＜ 0.05).Logistic regression showed that age (odds ratio =1.86,95％ confidence interval:1.37-2.19,P =0.019 1),H-type hypertension (odds ratio =6.18,95％ confidence interval:3.45-10.87,P ＜0.000 1),non-dipper or anti-dipper blood pressure(odds ratio =5.68,95％ confidence interval:4.15-11.08,P =0.001 4),smoking history (odds ratio =4.33,95％ confidence interval:2.08-9.02,P =0.012 5),diabetes history (odds ratio =2.10,95％ confidence interval:1.49-3.04,P =0.021 8) and total cholesterol level(odds ratio =3.15,95％ confidence interval:1.88-6.04,P =0.009 7) were risk factors of ASCVD.There was a positive correlation between ASCVD and Hcy level (r =3.041,P ＜ 0.05).Conclusions Patients with H-type hypertension are more likely to develop ASCVD.Non-dipper or anti-dipper blood pressure and elevated blood Hcy level in H-type hypertension patients may increase the risk of ASCVD.