Correlation between smoking and serum total bilirubin in male patients with coronary atherosclerotic heart disease
Wang Su
Zhang Jingmei
Zhang Yanyan
Li Nan
Lin Yun
Zhang Donghua
Huang Ji
Cheng Yutong
Li Zhizhong
Abstract：Objective To investigate the correlation between smoking and serum total bilirubin in male patients with coronary atherosclerotic heart disease(CHD).Methods From January 2009 to December 2012,1 902 male patients diagnosed of CHD in Beijing Anzhen Hospital,Capital Medical University were divided into smoking group(n =984),smoking cessation group (n =325) and non-smoking group (n =593).The relation between smoking and serum total bilirubin level was analyzed.Results Serum total bilirubin level in smoking group was significantly lower than that in smoking cessation group and non-smoking group[12.20(3.34,56.90)μmol/L vs 13.50(3.60,49.86),14.12(4.32,57.61)μmol/L] (both P ＜0.017);there was no significant difference of total bilirubin between smoking cessation group and non-smoking group(P ＞ 0.017).The smoking group was divided into three subgroups according to daily smoking amount:1-10 cigarettes/d group (n =166),11-20 cigarettes/d group (n =591) and ＞20 cigarettes/d group(n =227).Serum total bilirubin level in the 1-10 cigarettes/d group was significantly higher than that in the other two groups(both P ＜0.017);there was no significant difference between 11-20 cigarettes/d group and ＞ 20 cigarettes/d group(P ＞ 0.017).According to smoking duration,the smoking group was divided into three subgroups:1-20 years group(n =285),21-30 years group(n =420) and ＞ 30 years group(n =279)];there was no significant difference of total bilirubin among the three groups(P =0.683).The smoking cessation group was divided into two subgroups according to quitting time:＜ 2 years group(n =100) and ≥2 years group(n =225)];there was no significant difference of total bilirubin level between the two groups (P =0.278).Spearman rank correlation analysis showed that smoking was negatively correlated with serum total bilirubin level(ri =-0.173,P ＜ 0.001).Smoking,11-20 cigarettes/d,＞ 20 cigarettes/d,1-20 years,21-30 years and ＞ 30 years were independent risk factors of low total bilirubin(serum total bilirubin ＜ 10.25 μmoL/L) (all P ＜0.05).Conclusions Smoking,especially more than 10 cigarettes daily,is a risk factor of low serum total bilirubin in male patients with CHD.Quiting smoking can help increase serum total bilirubin.
Keywords：Coronary heart diseaseCigarette smokingTotal bilirubin
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1616-1619 )