Clinical effect of metoprolol combined with Wenxin granules on atrial fibrillation

Wu Zhigang

doi:10.3760/j.issn.1673-4777.2018.11.004

Abstract：Objective To analyze the clinical effect of Wenxin granules combined with metoprolol on atrial fibrillation.Methods A total of 105 patients with atrial fibrillation were enrolled from March to December 2017 in the Affiliated Hospital of Datong University.They were randomly divided into observation group(n =53) and control group(n =52).On the basis of routine treatment,the control group was treated with metoprolol;the observation group was treated with metoprolol plus Wenxin granules.Clinical effect and adverse reactions were observed.Results After treatment,frequency of atrial fibrillation in 24 h,duration of atrial fibrillation and resting heart rate in the observation group were less than those in the control group[(5.0 ± 0.4)times vs (9.8 ± 0.7)times,(70±7)min vs (132±17)min,(79±7)times/min vs (90±9)times/min] (P＜0.05).Left ventricular end-systolic diameter,left ventricular end-diastolic diameter in the observation group were lower than those in the control group;fractional shortening,left ventricular ejection fraction,cardiac index and cardiac output in the observation group were higher than those in the control group[(43 ±4)mm vs (48 ±4)mm,(49 ±4)mm vs (54 ±5)mm,(28.8±2.3)％ vs (23.8±2.2)％,(59±4)％ vs (53±4)％,(2.5 ±0.3)L/(min· m2) vs (2.0 ± 0.2) L/(min · m2),(96 ± 9) ml vs (82 ± 9) ml] (P ＜ 0.05).There was no significant difference of adverse reactions between the observation group and control group[9.6％ (5/52) vs 7.5％ (4/53)] (P ＞ 0.05).Conclusion Metoprolol combined with Wenxin granules treating atrial fibrillation can effectively improve heart function,stabilize heart rate,reduce the frequency and duration of atrial fibrillation.