Expressions of tumor markers and Ki-67 in triple-negative and non-triple-negative breast cancer

Xing Fanglin; Xu Rui; Zhang Lulu; Jiao Wei; Duan Wenbing; Li Xiaoying; Zhao Wanhui

doi:10.3760/j.issn.1673-4777.2018.09.023

Abstract：Objective To investigate the expressions of tumor markers and Ki-67 in triple-negative breast cancer(TNBC) and non-TNBC.Methods From August 2016 to May 2017,clinical records of 184 patients with breast cancer(32 TNBC and 152 non-TNBC) and 41 patients with benign breast disease in Shandong Provincial Hospital Affiliated to Shandong University were collected.Carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125) and CA153 were detected by chemiluminescence.Ki-67 was detected by immunohistochemistry.The relation between clinicopathological features of breast cancer and Ki-67 expression was analyzed.Results Levels of CA125 and CA153 in TNBC were significantly higher than those in non-TNBC and benign breast disease(P ＜0.05).CEA level in TNBC and non-TNBC was significantly higher than that in benign breast disease(P ＜ 0.05),but there was no significant difference between TNBC and non-TNBC (P ＞ 0.05).In TNBC,tumor diameter was ≤2 cm in 7 cases and ＞2 cm in 25 cases;22 patients(68.8％) had lymphatic metastasis.In non-TNBC,there were 66 cases of tumor diameter≤2 cm and 86 cases of tumor diameter ＞2 cm;72 patients(47.4％) had lymphatic metastasis.Tumor diameter,lymphatic metastasis,age and histological grade showed no significant difference between TNBC and non-TNBC (P ＞ 0.05).Expression of Ki-67 in TNBC was higher than that in non-TNBC [40％ (20％,42％) vs 20％ (15％,30％)] (P ＜ 0.05).Expression of Ki-67 showed no significant difference among breast cancer patients with different age,tumor diameter,lymphatic metastasis and histological grade (P ＜ 0.05).Conclusion TNBC patients have high expression of Ki-67,high rate of lymph node metastasis and large tumor size;CEA,CA153 and CA125 are important diagnostic indicators of TNBC.