Clinical effect of alprostadil on severe acute pancreatitis, intestinal mucosa barrier function and gastrointestinal motility
Han Kun
Abstract：Objective To observe the curative effect of alprostadil on patients with severe acute pancreatitis (SAP) and the impact on intestinal mucosa barrier function and gastrointestinal motility.Methods Totally 94 SAP patients admitted from January 2016 to January 2018 in Xi'an Central Hospital were randomly divided into control group and observation group,with 47 cases in each group.The control group had traditional therapy;the observation group was treated with alprostadil injection additionally,10 d was 1 course.Clinical symptoms recovery time,blood and urine amylase recovery time,intestinal mucosal barrier function and gastrointestinal motility indicators,electrogastrographic parameters,complications,surgical transfer rate and mortality were analyzed.Results After treatment,abdominal pain and distension relief time,bowel sound recovery time,the first defecation time,blood and urine amylase recovery time in the observation group were significantly shorter than those in the control group [(3.3 ±0.5)d vs (4.9 ±0.7)d,(3.7 ±0.9)d vs (5.2 ±0.7)d,(2.1 ±0.4)d vs (3.1 ±0.6)d,(5.1 ±0.9) d vs (7.3 ± 1.2) d,(5.6 ± 1.0) d vs (7.9 ± 1.5) d] (P ＜ 0.05);levels of D-lactic acid,diamine oxidase,endotoxin,gastrin and vasoactive intestinal peptide in the observation group were significantly lower than those in the control group[(2.68 ± 0.24) mg/L vs (3.70 ± 0.82) mg/L,(7.8 ± 1.2) U/L vs (13.0 ± 3.2) U/L,(32 ±6)EU/L vs (47 ±9)EU/L,(135 ± 15) μmol/L vs (176 ±25) μ mol/L,(5.3 ±0.9) μmol/L vs (6.5 ±1.7) μmol/L];motilin and cholecystokinin levels,mean amplitude and principal frequency of electrogastrogram in the observation group were significantly higher than those in the control group[(214 ± 27)ng/L vs (180 ± 32)ng/L,(131 ±25)ng/L vs (106 ±15)ng/L,(169 ±27) μV vs (143 ± 13)μV,(2.89 ±0.37)CPM vs (2.60 ±0.25)CPM](P ＜ 0.05).Incidence of complications in the observation was significantly lower than that in the control group (P ＜ 0.05).There were no significant differences of surgical transfer rate and mortality between the two groups (P ＞ 0.05).Conclusion Alprostadil is effective in treatment of SAP;it can promote the recovery of intestinal mucosa barrier function and gastrointestinal motility and reduce the incidence of complications.
Keywords：Severe acute pancreatitisAlprostadilIntestinal mucosa barrierGastrointestinal motility
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1365-1368 )