Effect of octreotide combined with growth hormone on inflammatory factors, immune function and hemorheology in critical patients with acute pancreatitis
Luo Yong
Abstract：Objective To investigate the effect of octreotide combined with growth hormone on inflammatory factors,immune function and hemorheology in patients with acute pancreatitis (AP) in intensive care unit.Methods From January 2015 to May 2017,80 AP patients were enrolled from Intensive Care Unit of Huangpi District People's Hospital of Wuhan City.The patients were randomly divided into control group(38 cases) and observation group (42 cases).The control group was treated with octreotide on the basis of routine treatment.The observation group was treated with growth hormone on the basis of control group.All patients were treated continuously for 5 days.Inflammatory factors,immune function and hemorheological indexes were analyzed before and after treatment.Results After treatment,levels of serum C-reactive protein,tumor necrosis factor-α,interleukin-6 and interleukin-10 in the observation group were significantly lower than those in the control group[(87 ±27) mg/L vs (121 ±26)mg/L,(115 ±55)ng/L vs (152 ±50) ng/L,(114 ± 16)ng/L vs (208 ± 15)ng/L,(69 ±25)ng/L vs (90 ±22)ng/L];ratios of CD3+,CD4+,CD4+/CD8+ in the observation group were significantly higher and the ratio of CD8+ was significantly lower than those in the control group;the whole blood high shear viscosity,plasma viscosity,thrombus length and platelet adhesion rate in the observation group were significantly lower than those in the control group(P ＜ 0.05).Conclusion Octreotide combined with growth hormone can reduce inflammatory factors,improve immune function and hemorheology in patients with acute pancreatitis.
Keywords：Acute pancreatitisOctreotideGrowth hormoneInflammatory factorsImmune functionHemorheology
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1361-1364 )