Effect of Shuganning injection combined with reduced glutathione on liver function and serum T lymphocytes in primary liver cancer patients after transcatheter arterial chemoembolization
Dou Wei
Li Yanjiao
Zhang Jie
Zhang Yongkai
Abstract：Objective To analyze the effect of Shuganning injection combined with reduced glutathione on liver function and serum T lymphocytes in primary liver cancer patients after transcatheter arterial chemoembolization (TACE).Methods A total of 120 patients with primary liver cancer who had TACE from March 2016 to July 2017 were enrolled in the First Hospital of Jilin University.The patients were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with reduced glutathione.The observation group was treated with Shuganning injection combined with reduced glutathione.Liver function indexes and serum T lymphocytes were analyzed.Results Levels of alanine aminotransferase (ALT),aspartate aminotransferase(AST),total bilirubin and direct bilirubin (DBIL) showed no significant differences between groups before treatment(P ＞ 0.05).After treatment,ALT,AST,total bilirubin and DBIL in the observation group were significantly lower than those in the control group [(53 ± 8) U/L vs (69 ± 11) U/L,(53 ± 9) U/L vs (68 ±11) U/L,(19 ±4) μmol/L vs (23 ±4) μmol/L,(7 ±3) μmol/L vs (9 ±4) μmol/L] (P ＜0.05).CD4+ T/CD8+ T ratio showed no significant difference between groups before treatment(P ＞ 0.05).After treatment,CD4+ T/CD8+ T ratio in the observation group was significantly higher than that in the control group [(1.36 ± 0.11) vs (1.03 ±0.14)] (P ＜ 0.05).Conclusion Shuganning injection combined with reduced glutathione treating post-TACE primary liver cancer patients can effectively improve liver function and T lymphocyte balance.
Keywords：Primary liver cancerTranscatheter arterial chemoembolizationShuganning injectionReduced glutathioneLiver functionSerum T lymphocytes
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1349-1352 )