Effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with retinopathy

Pang Xiaoning; He Xiaoyi; Liu Yanjun

doi:10.3760/j.issn.1673-4777.2018.09.016

Abstract：Objective To investigate the effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with diabetic retinopathy(DR).Methods From June 2016 to June 2017,266 type 2 diabetic patients with DR were enrolled in the Third Hospital of the Chinese People's Liberation Army.All patients took vitamin E 100 mg/d after breakfast for 3 months.Fundus condition was examined and the patients were divided into 4 groups according to the international grading standards:non-proliferative mild DR (group Ⅰ,n =69),moderate DR(group Ⅱ,n=61),severe DR(group Ⅲ,n=47) and proliferative DR(group Ⅳ,n =89).Serum malondialdehyde level was analyzed before and after treatment.Results Before treatment,malondialdehyde in group Ⅲ and group Ⅳ was significantly higher than that in group Ⅰ [(4.42 ±0.15),(4.84 ±0.17) μmoL/L vs (3.62 ± 0.11) μmol/L] (P ＜ 0.05 or P ＜ 0.01).After treatment,malondialdehyde in group Ⅰ,Ⅱ,Ⅲ and Ⅳ [(3.44 ±0.13),(3.71 ±0.16),(4.18 ±0.17),(4.72 ±0.14) μmol/L] was significantly lower than that before treatment;malondialdehyde in group Ⅳ was significantly higher than that in group Ⅰ (P ＜ 0.05).There was no significant difference of malondialdehyde level between male and female patients before and after treatment (P ＞ 0.05).Whether in males or females,malondialdehyde in group Ⅰ,Ⅱ,Ⅲ and Ⅳ after treatment was significantly lower than that before treatment (P ＜ 0.05).Conclusion Vitamin E has an effect on serum malondialdehyde level,which is related to the severity of DR in patients with type 2 diabetes.