Anesthetic effect of sufentanil plus cisatracurium besilate on patients undergoing lung cancer surgery

Zhu Yi; Zheng Lina; Wu Yibin

doi:10.3760/j.issn.1673-4777.2018.09.008

Abstract：Objective To analyze the anesthetic effect of sufentanil plus cisatracurium besilate on patients undergoing lung cancer surgery.Methods Ninety patients undergoing lung cancer surgery from March 2016 to June 2017 in Shanxi Provincial Cancer Hospital were randomly divided into control group and observation group,with 45 cases in each group.Patients in the control group had intravenous general anesthesia with propofol,etomidate and fentanyl;the observation group had midazolam,propofol,sufentanil plus cisatracurium besilate anesthesia.Serum levels of angiotensin Ⅱ (Ang-Ⅱ),cortisol and malondialdehyde were tested 1,48 h after surgery.Occurrence of complications was observed.Ramsay sedation score and Observer's Assessment of Alertness/Sedation (OAA/S) score were assessed.Results Serum levels of Ang-Ⅱ,cortisol (Cor)and malondialdehyde(MDA) at 1,48 h after surgery in the observation group were significantly lower than those in the control group[Ang-Ⅱ:(34 ±3)ng/L vs (65 ±4)ng/L,(35 ±4)ng/L vs (64 ±4)ng/L;Cor:(139 ± 19) μg/L vs (238 ±25) μg/L,(139 ±16) μg/L vs (237 ± 31) μg/L;MDA:(0.13 ± 0.04) μg/L vs (0.32 ± 0.08) μg/L,(0.14 ± 0.07) μg/L vs (0.34 ± 0.08) μg/L] (P ＜ 0.05).Incidence of postoperative complications in the observation group (1 agitation,2 nausea and vomiting,1 hypoxemia) was significantly lower than that in the control group(3 agitation,7 nausea and vomiting,4 hypoxemia) [8.9％ (4/45) vs 31.1％ (14/45)] (P ＜0.05).Ramsay sedation score and OAA/S score in the observation group were significantly higher than those in the control group[(3.11 ± 0.13) vs (1.35 ±0.12),(5.14 ± 0.22) vs (3.02 ± 0.43)] (P ＜ 0.05).Conclusion Sufentanil plus cisatracurium besilate has a good anesthetic effect on patients with lung cancer surgery;serum levels of Ang-Ⅱ,cortisol and malondialdehyde can be significantly lowered and stress response can be relieved.