Diagnostic value of serum procalcitonin in heart failure complicated with infection
Su Yan
Zhang Yue
Liu Yiqing
Liu Lingling
Liu Yun
Wang Yong
Zhang Bingchang
Abstract：Objective To investigate the diagnostic value of serum procalcitonin in heart failure complicated with infection.Methods From June 2014 to May 2015,187 patients were enrolled in Shandong Provincial Hospital Affiliated to Shandong University,including 59 simple infection,63 heart failure and 65 infection with heart failure [New York Heart Association(NYHA) grade Ⅱ 21 cases,grade Ⅲ 23 cases,grade Ⅳ 21 cases];100 healthy people were enrolled as control group.Serum procalcitonin was tested using the Roche Cobas E601 chemiluminescence immunoassay analyzer.Results The level of serum procalcitonin in simple infection group,heart failure group and heart failure with infection group was significantly higher than that in control group [(9.32 ± 4.98),(3.21 ± 2.65),(19.33 ± 9.76) μg/L vs (0.05 ± 0.03) μg/L];the level of procalcitonin in heart failure with infection group was significantly higher than that in simple infection group(all P ＜ 0.01).With procalcitonin =0.05 μg/L as the diagnostic threshold,the sensitivity and negative predictive value increased with NYHA heart failure grade,while the positive predictive value decreased gradually.Conclusions Heart failure can lead to the increase of serum procalcitonin level.Procalcitonin =0.05 μg/L shows different diagnostic efficiency among patients with simple infection and different grades of heart failure complicated with infection.
Keywords：Heart failureProcalcitoninDiagnostic threshold
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1285-1287 )