Effect of intravenous administration of tranexamic acid on blood loss and thrombotic complication in patients undergoing knee joint replacement surgery
Quan Shengbing
Chen Jianhua
Bao Yizhang
Abstract：Objective To explore the effect of intravenous administration of tranexamic acid on blood loss and thrombotic complication in patients undergoing knee joint replacement surgery.Methods Totally 121 patients undergoing knee joint replacement surgery from June 2014 to June 2017 in the Third People's Hospital of Xining were randomly divided into observation group (n =61) and control group (n =60).The observation group had intravenous administration of tranexamic acid and the control group had intravenous administration of 0.9％ sodium chloride solution during anesthesia induction.Blood loss volume,occurrence of thrombotic complications and knee rehabilitation were analyzed.Results Blood transfusion rate in observation group was significantly lower than that in control group[16.4％ (10/61) vs 43.3％ (26/60)] (P =0.005).Intraoperative blood loss showed no significant difference between groups (P ＞ 0.05).Postoperative drainage,dominant blood loss,hidden blood loss,blood transfusion volume and total blood loss in observation group were significantly less than those in control group [(391 ±61)ml vs (481 ±90)ml,(500 ±92)ml vs (587 ± 103)ml,(361 ±52)ml vs (456 ±64)ml,(232 ± 9l) ml vs (404 ± 169) ml,(862 ± 116) ml vs (1 044 ± 182) ml] (P ＜ 0.001).Incidences of limb subcutaneous ecchymosis,deep venous thrombosis and pulmonary embolism showed no significant difference between groups (P＞ 0.05).Before surgery,crus circumference and suprapatellar 10 cm circumference had no significant differences between groups (P ＞ 0.05).Two weeks after surgery,crus circumference and suprapatellar 10 cm circumference in observation group were significantly less than those before surgery and those in control group(P ＜0.001).Before surgery,American Knee Society knee score (KSS) had no significant difference between groups (P ＞ 0.05).After surgery,KSS significantly increased in both groups;KSS in observation group was significantly higher than that in control group (P ＜ 0.001).Conclusion Intravenous infusion of tranexamic acid helps to reduce blood loss and promote knee joint rehabilitation in patients undergoing knee replacement surgery;it does not increase the risk of thrombotic complication.
Keywords：Knee replacementTranexamic acidBlood lossThrombotic complication
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1200-1204 )