Effect of transcatheter arterial chemoembolization with sequential radiofrequency ablation on liver multiple tumors

Xiao Chaohui; Wang Zhaohai; Yu Lingxiang; Sun Jiayi; Diao Guanghao; Zhang Shaogeng

doi:10.3760/j.issn.1673-4777.2018.08.016

Abstract：Objective To analyze the effect of transcatheter arterial chemoembolization (TACE) with sequential radiofrequency ablation on Barcelona Clinic Liver Cancer(BCLC) stage B patients.Methods Forty-five BCLC stage B liver cancer patients admitted in the 302th Military Hospital of the Chinese People's Liberation Army from May 2012 to June 2014 were analyzed.All patients had TACE with sequential radiofrequency ablation.According to the number and diameter of tumors,the patients were divided into group A (number of tumors ＞ 3,diameter of tumors ≤5 cm,n =16) and group B (1 ＜ number of tumors ≤ 3,diameter of one of tumors ≥5 cm,n =29).Changes of serum alpha-fetoprotein level before and after operation,short-and long-term curative effects were analyzed.Results Serum levels of alpha-fetoprotein 1 month after operation of all patients,group A and group B were significantly lower than those before treatment[(203 ± 109) μg/L vs (453 ± 146) μg/L,(253 ± 121) μg/L vs (411 ± 106) μg/L,(199 ±79) μg/L vs (518 ± 156) μg/L] (P ＜0.05).Two months after treatment,group A had 10 cases(62.5％) of complete remission and 3 cases(18.8％) of partial remission;group B had 22 cases (75.9％) of complete remission and 4 cases(13.8％) of partial remission;there were no significant differences of the remission rates between groups(P ＞0.05).Three-year disease free survival rates of group A,group B and all patients were 18.8％ (3/16),27.6％ (8/29) and 24.4％ (11/45);3-year overall survival rates were 25.0％ (4/16),37.9％ (11/29) and 33.3％ (15/45);there were no significant differences of the survival rates among groups (P ＞0.05).Conclusion TACE with sequential radiofrequency ablation has a satisfactory curative effect on BCLC stage B liver cancer.