Relation among tumor cell detection rate and expressions of matrix metalloproteinase-7 and carcinoembryonic antigen in peritoneal lavage fluid of patients undergoing open and laparoscopic radical resection of gastric cancer
Wei Hailong
Abstract：Objective To investigate the relation among tumor cell detection rate and expressions of matrix metalloproteinase-7 (MMP-7) and carcinoembryonic antigen (CEA) in peritoneal lavage fluid of patients undergoing open and laparoscopic radical resection of gastric cancer.Methods Thirty-six patients undergoing laparoscopic radical gastrectomy and 40 patients undergoing open gastrectomy for gastric cancer were enrolled from October 2014 to March 2017 in People's Hospital of Danzhou.Peritoneal lavage fluid was collected before and after resection of gastric tumor;tumor cell detection rate and expressions of MMP-7 and CEA in lavage fluid were tested.Results There were no significant differences of positive expression rates of MMP-7 and CEA in peritoneal lavage fluid between open gastrectomy patients and laparoscopic gastrectomy patients (P ＞ 0.05).There was no significant difference of tumor cell detection rate in peritoneal lavage fluid between open gastrectomy patients and laparoscopic gastrectomy patients(P ＞0.05).After resection of tumor,19 open gastrectomy patients were detected tumor cells in peritoneal lavage fluid,among them 18 cases (94.7％) showed positive MMP-7 and 17 cases (89.5％) showed positive CEA;21 patients had negative results of tumor cell detection,including 12 cases (57.1％) with positive MMP-7 and 4 cases(19.0％) with positive CEA;tumor cell detection rate was positively related to expressions of MMP-7 and CEA (r =0.553,0.704;P ＜ 0.05).After resection of tumor,16 laparoscopic gastrectomy patients were detected tumor cells in peritoneal lavage fluid,15 cases (93.8％) of them showed positive MMP-7 and 14 cases(87.5％) showed positive CEA;20 patients had negative results of tumor cell detection,11 cases(55.0％) had positive MMP-7 and 5 cases(25.0％) had positive CEA;tumor cell detection rate was positively related to expressions of MMP-7 and CEA (r =0.430,0.622;P ＜ 0.05).Conclusions Tumor cell detection rate is closely related to expressions of MMP-7 and CEA in peritoneal lavage fluid of patients with radical resection of gastric cancer.Laparoscopic gastrectomy will not increase the possibility of tumor cell dissemination.
Keywords：Gastric neoplasmsLaparoscopyMatrix metalloproteinase-7Carcinoembryonic antigen
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1176-1180 )