Effect of palonosetron combined with FOLFOX4 chemotherapy on gastrointestinal reaction in gastric cancer patients after radical gastrectomy

Ma Jinxin; Song Wei; Feng Xiemin

doi:10.3760/j.issn.1673-4777.2018.08.014

Abstract：Objective To explore the effect of palonosetron combined with FOLFOX4 chemotherapy on gastrointestinal reaction in gastric cancer paticnts after radical gastrectomy.Methods A total of 100 patients with gastric cancer who had radical gastrectomy from March 2014 and March 2017 in Yan'an University Affiliated Hospital were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with dexamethasone combined with FOLFOX4 chemotherapy;the observation group was treated with palonosetron on the basis of control group.Serum levels of motilin and gastrin,occurrences of gastrointestinal reactions and other adverse reactions and efficacy of chemotherapy were analyzed.Results Sixteen patients were withdrawn from the test.Serum levels of motilin and gastrin had no significant differences between observation group(n =42) and control group (n =42) before chemotherapy (P ＞ 0.05).After chemotherapy,serum level of motilin significantly decreased compared to that before chemotherapy in both groups;serum level of motilin in observation group was significantly lower than that in control group[(83 ± 8)ng/L vs (92 ± 9)ng/L] (P ＜ 0.05).After chemotherapy,serum level of gastrin significantly increased compared to that before chemotherapy in both groups;serum level of gastrin in observation group was significantly higher than that in control group [(330 ± 88) μg/L vs (283 ± 72) μg/L] (P ＜ 0.05).Effective control rates of acute nausea,delayed nausea,acute vomiting,delayed vomiting in observation group were significantly higher than those in control group[90.5％ (38/42) vs 59.5％ (25/42),83.3％(35/42) vs 50.0％ (21/42),85.7％ (36/42) vs 57.1％ (24/42),81.0％ (34/42) vs 52.4％ (22/42)] (P ＜ 0.05).Incidence of non-gastrointestinal reactions and effective rate of chemotherapy showed no significant differences between groups(P ＞ O.05).Conclusion Palonosetron combined with FOLFOX4 chemotherapy treating postoperative gastric cancer patients can effectively improve serum levels of motilin and gastrin and reduce gastrointestinal reactions.