Use of proton pump inhibitors in prevention of stress ulcer during perioperative period
Xu Sha
Chen Xi
Xu Xiaoyu
Liu Zhijun
Peng Wenxing
Lin Yang
Abstract：Objective To investigate the use of proton pump inhibitors(PPI) in prevention of stress ulcer during perioperative period and to promote the rational use of PPI.Methods Clinical data of 104 cardiac surgery patients who were treated with PPI for prevention of stress ulcer in September 2016 at Beijing Anzhen Hospital,Capital Medical University were retrospectively cdlected.Risk factors and indications,types and doses,medication timing and course of PPI were analyzed.Results Nine patients(8.7％) had no PPI indication.Thirty-seven patients(35.6％) used 1 kind of PPI;50 patients(48.1％) used 2 kinds of PPI;16 patients(15.4％) used 3 kinds of PPI;1 patients(1.0％) used 4 kinds of PPI.Eighteen patients were treated with PPI plus warfarin;13 of them used esomeprazole;7 patients used lansoprazole;2 patients used pantoprazole;2 patients used omeprazole;2 patients used rabeprazole;38.2％ (68/178) of patients took PPI 2 times/d and others took PPI 1 time/d.Four patients had PPI before operation;100 patients had PPI after operation.Medication course of PPI was 1-16 d;48.1％ (50/104) of patients still used PPI after risk factors disappeared.Two patients (1.9％) had bleeding events.Nine patients(8.7％) had pneumonia.No Clostridium difficile infection occurred.Conclusion There are irrational uses of PPI in cardiac surgery department such as excessive types and long medication duration.
Keywords：Stress ulcerProton pump inhibitorsRational drug use
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1168-1171 )