Effects of etomidate and propofol anesthesia on oxidative stress and brain injury in patients undergoing intracranial aneurysm interventional operation

Xu Yan; Chen Youlin

doi:10.3760/j.issn.1673-4777.2018.08.011

Abstract：Objective To explore the effects of etomidate and propofol anesthesia on oxidative stress and brain injury in patients undergoing intracranial aneurysm interventional operation.Methods Eighty patients undergoing intracranial aneurysm interventional operation from january 2015 to June 2016 in the First People's Hospital of Yibin were randomly divided into etomidate group and propofol group,with 40 cases in each group.All patients were treated with the same anesthesia induction;the propofol group had propofol 2-4 mg/L and the etomidate group had etomidate 0.3-0.6 mg/(kg · h) for anesthesia maintenance.Levels of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),neuro-specific enolase(NSE),S100β,mean arterial pressure and heart rate were analyzed.Results Levels of SOD,CAT and GSH-Px at 24,48,72 h after operation in etomidate group were significantly higher than those in propofol group;levels of NSE and S100β at 24,48,72 h after operation in etomidate group were significantly lower than those in propofol group(P ＜ 0.05).Mean arterial pressure and heart rate before and during intubation in propofol group were significantly lower than those in etomidate group;mean arterial pressure and heart rate during extubation in propofol group were significantly higher than those in etomidate group [mean arterial pressure:(112 ± 22) mmHg vs (119 ± 23) mmHg,(105 ± 25) mmHg vs (126 ± 24) mmHg,(133 ± 27) mmHg vs (125 ± 23) mmHg;heart rate:(80 ± 12) times/min vs (87 ± 12) times/min,(78 ±12) times/min vs (87 ± 12)times/min,(97 ± 15)times/min vs (85 ± 11)times/min] (P ＜0.05).Conclusion Etomidate anesthesia can reduce stress response and protect the brain more significantly than propofol in patients undergoing cerebral aneurysm interventional operation.