Prevalence and clinical characteristics of natural anticoagulant deficiency in Chinese Han patients with unprovoked pulmonary thromboembolism
Wang Zengzhi
Zhao Xiuqing
Li Jie
Gao Yang
Zhang Xiangfeng
Liu Shuang
Abstract：Objective To investigate the prevalence rate of deficiency of natural anticoagulants (NA) including protein C,protein S and antithrombin Ⅲ in Chinese Han patients with unprovoked pulmonary thromboembolism (uPTE) and to analyze the clinical characteristics of NA deficiency.Methods A total of 265 Chinese Han patients with uPTE who visited Beijing Anzhen Hospital,Capital Medical University from January 2010 to December 2017 were retrospectively analyzed.Expressions of protein C,protein S and antithrombin Ⅲ were detected.Clinical data were analyzed between patients with and without NA deficiency.Results Prevalence rate of NA deficiency in 265 Chinese Han uPTE patients was 34.3％ (n =91).Thirty-one patients had protein C plus protein S deficiency;28 patients had simple protein S deficiency;22 patients had simple protein C deficiency;which were the top 3 common deficiency patterns.Combined NA deficiency rate was 13.6％ (36/265).Age,onset age of pulmonary thromboembolism and incidence of dyspnea in patients with NA deficiency were significantly lower than those in patients without NA deficiency[(55 ± 13)years vs (64 ± 11)years,(50 ± 14)years vs (63 ±12)years,40.7％ (37/91) vs 56.3％ (98/174)];family history of venous thrombosis ratio in patients with NA deficiency was significantly higher than that in patients without NA deficiency [23.1％ (21/91) vs 3.4％ (6/174)](P ＜ 0.05).Conclusions Prevalence rate of NA deficiency is high in Chinese Han patients with uPTE.Patients with NA deficiency may suffer from uPTE at a young age;dyspnea is uncommon;family history of venous thrombosis may increase the risk of disease.
Keywords：Unprovoked pulmonary thromboembolismHereditary thrombophiliaNatural anticoagulant
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1156-1159 )