Effect of recombinant human brain natriuretic peptide on prognosis of acute left heart failure after emergency coronary intervention in elderly patients with acute myocardial infarction
Zu Xiaolin
Zeng Yujie
Zhang Feng
Wang Chenggang
Gao Hai
Abstract：Objective To explore the effect of recombinant human brain natriuretic peptide(rhBNP) on prognosis of acute left heart failure after emergency coronary intervention in elderly patients with acute myocardial infarction.Methods A total of 207 elderly patients who had acute left heart failure after coronary intervention for myocardial infarction were enrolled from January 2014 to January 2016 in Beijing Anzhen Hospital,Capital Medical University.According to different therapeutic measures,the patients were divided into rhBNP group(n =68) and control group (n =139).Heart function and dyspnea recovery were observed.Occurrence of major adverse cardiovascular events(MACE) was followed up in 1 year after treatment.Risk factors of MACE were analyzed by multivariate logistic regression.Results After treatment,heart rate in rhBNP group was significantly lower,mean arterial pressure and left ventricular ejection fraction were significantly higher than those in control group [(88 ±15)times/minvs(97±12)times/min,(87±5)mmHg vs(79±6)mmHg,(35±10)％ vs(33±7)％](P＜0.05).Total effective rate of expiratory dyspnea in rhBNP group was significantly higher than that in control group [86.7％ (59/68) vs 70.0％ (97/139)] (P ＜ 0.01).One-year MACE rate showed no significant difference between groups (P ＞ 0.05).Logistic regression analysis demonstrated that N-terminal pro-B-type natriuretic peptide(NT-proBNP) (odds ratio =0.842,95％ confidence interval:0.532-0.948,P =0.002) and left ventricular ejection fraction(odds ratio =0.743,95％ confidence interval:0.631-0.803,P =0.004) were risk factors of MACE.Conclusions RhBNP can improve cardiac function,alleviate dyspnea and reduce MACE in elderly myocardial infarction patients with acute left heart failure after coronary intervention.NT-proBNP and left ventricular ejection fraction are risk factors of the prognosis.
Keywords：Heart failureRecombinant human brain natriuretic peptideMajor adverse cardiovascular events
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1141-1144 )