Clinical effect of atorvastatin calcium combined with ezetimibe on acute coronary syndrome
Chen Ying
Xia Jinggang
Abstract：Objective To analyze the clinical effect of atorvastatin calcium combined with ezetimibe on acute coronary syndrome(ACS).Methods A total of 136 ACS patients admitted from April 2016 to March 2017 in Xuanwu Hospital,Capital Medical University were randomly divided into control group(n =65) and combined treatment group (n =71).The control group was treated with atorvastatin calcium 20 mg/d;the combined treatment group was treated with atorvastatin calcium 20 mg/d and ezetimibe 10 mg/d;both groups were treated for 24 weeks.Blood lipid index and high-sensitivity C-reactive protein (hs-CRP) level,cardiovascular events and adverse reactions were analyzed.Results After 24 weeks of treatment,levels of low-density lipoprotein cholesterol (LDL-C),total cholesterol and hs-CRP were significantly lower than those before treatment in both groups;levels of LDL-C,total cholesterol and hs-CRP in combined treatment group were significantly lower than those in control group [(1.97 ± 0.51) mmol/L vs (2.20 ± 0.33) mmol/L,(2.6 ± 0.6) mmol/L vs (3.2 ± 0.5) mmol/L,(1.7 ± 1.1) mg/L vs (2.2 ± 1.2) mg/L] (P ＜ 0.05).Incidence rates of recurrent angina and recurrent myocardial infarction in combined treatment group were significantly lower than those in control group [5.6％ (4/71) vs 15.4％ (10/65),1.4％ (1/71) vs 12.3％ (8/65)] (P ＜ 0.05).Incidence of adverse reactions in combined treatment group was significantly lower than that in control group [5.6％ (4/71) vs 30.8％ (20/65)] (P ＜ 0.05).Conclusion Atorvastatin calcium combined with ezetimibe treating ACS can effectively regulate blood lipid and reduce cardiovascular events and adverse reactions.
Keywords：Acute coronary syndromeAtorvastatin calciumEzetimibe
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1126-1128 )