Risk factors of non-target lesion progression in patients after percutaneous coronary intervention

Ma Qian; Zhou Yujie; Zhang Linlin; Zhao Yingxin; Wang Jianlong; Wang Zhijian

doi:10.3760/j.issn.1673-4777.2018.08.001

Abstract：Objective To investigate the risk factors of non-target lesion progression in patients after percutaneous coronary intervention(PCI).Methods From January 2013 to December 2016,a total of 3 071 patients who underwent single-vessel PCI for acute coronary syndrome were enrolled in Beijing Anzhen Hospital,Capital Medical University.Remaining non-target stenoses were ＜ 50％.All patients were readmitted to hospital due to chest pain within 6 to 24 months after PCI.According to coronary angiography results at readmission,they were divided into group A(n =1 541) and group B(n =1 530);patients in group A had non-target lesion progression (stenoses ＞75％);non-target stenoses of patients in group B were ＜ 75％.Related clinical data and influence factors of non-target lesion progression were analyzed.Results There were no significant differences of body mass index,non-target stenosis degree,low-density lipoprotein cholesterol(LDL-C) level and LDL-C compliance rate of the first time hospitalization between groups (P ＞ 0.05).At admission of the second time hospitalization,body mass index,non-target lesion stenosis degree and LDL-C level in group B were significantly lower than those in groupA[(25.5±2.9)kg/m2vs (26.2±3.2)kg/m2,(49 ±12)％ vs (85±5)％,(1.9±0.6)mmol/L vs(2.2 ±0.8)mmol/L];normal body mass index ratio,LDL-C compliance rate and regular statins-taking rate in group B were significantly higher than those in group A [51.6％ (790/1 530) vs 35.3％ (544/1 541),43.7％ (668/1 530) vs 35.4％ (545/1 541),84.8％ (1 298/1 530) vs 60.9％ (938/1 541)] (all P ＜ 0.05).Conclusion Poor patient compliance such as unauthorized withdrawal or dose reduction of drugs,poor weight and blood lipid control are risk factors of non-target lesion progression in patients after PCI.