Effectiveness and safety of fasudil combined with carbamazepine in treatment of epilepsy
Guo Xiaoxian
Gao Yan
Abstract：Objective To analyze the effectiveness and safety of fasudil combined with carbamazepine in treatment of epilepsy.Methods Totally 205 epileptic patients admitted from January 2014 to July 2017 in Yan'an People's Hospital were randomly divided into control group(n =102) and observation group(n =103).The control group took carbamazepine;the observation group were treated with carbamazepine combined with intravenous administration of fasudil.Negative emotion was assessed by the Zung Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale(SDS);cognitive function was assessed by the Montreal Cognitive Assessment (MoCA).Clinical curative effect,negative emotion,cognitive function and drug safety were analyzed.Results Total effective rate in observation group was significantly higher than that in control group[91.3％ (94/103) vs 81.4％ (83/102)] (P ＜ 0.05).SAS score,SDS score and MoCA score showed no significant differences between groups before treatment(P ＞ 0.05).After treatment,SAS score and SDS score in observation group were significantly lower than those in control group[(31 ± 4) vs (40 ± 5),(34 ± 5) vs (41 ± 4)];MoCA score in observation group was significantly higher than that in control group [(27 ± 6) vs (21 ± 6)] (P ＜ 0.05).Adverse drug reaction rate showed no significant difference between groups(P ＞ 0.05).Conclusion Fasudil combined with carbamazepine treating epilepsy can safely and effectively reduce negative emotion and improve cognitive function.
Keywords：EpilepsyFasudilCarbamazepineDrug safety
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1030-1033 )