Effect of acetylcysteine on pulmonary function, serum inflammatory factors and antioxidant indexes in patients with acute exacerbation of chronic obstructive pulmonary disease
Zhang Lin
Fan Xiaodong
Xu Hongyang
Abstract：Objective To investigate the effect of acetylcysteine on pulmonary function,serum inflammatory factors and antioxidant indexes in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods A total of 154 patients with acute exacerbation of COPD admitted from September 2015 toSeptember 2017 in Wuxi People's Hospital were randomly divided into control group and observation group,with 77 cases in each group.The control group were treated with conventional therapy;the observation group took acetylcysteine 600 mg/time,1-2 times/d on the basis of conventional therapy for 1 week.Lung function indexes [forced vital capacity (FVC),forced expiratory volume in 1 second (FEV1),FEV1/FVC],serum inflammatoryfactors [high-sensitivity C-reactive protein (hs-CRP),procalcitonin] and antioxidant indexes [malondialdehyde,superoxide dismutase(SOD),glutathione] were analyzed before and after treatment.Results After treatment,FVC,FEV1 and FEV1/FVC in observation group were significantly higher than those in control group[(2.87 ± 0.22)Lvs (2.64±0.54)L,(2.65 ±0.33)L vs (1.71±0.45)L,(67±7)％ vs (59±7)％](P＜0.05);serum levels of hs-CRP and procalcitonin in observation group were significantly lower than those in control group [(4.6 ±2.4)mg/L vs (9.4 ±3.8)mg/L,(0.31 ±0.26) μg/L vs (0.92 ±0.55) μg/L] (P ＜0.05);serum level of malondialdehyde in observation group was significantly lower,serum levels of SOD and glutathione were significantly higher than those in control group [(4.1 ± 0.6) μmol/L vs (7.3 ± 0.7) μmol/L,(82 ± 7) μg/L vs (71 ±7)μg/L,(162 ± 12) U/L vs (128 ± 13)U/L] (P＜0.05).Conclusion Acetylcysteine treating acute exacerbation of COPD can effectively inhibit inflammatory response,increase antioxidation and improve pulmonary function recovery.
Keywords：Chronic obstructive pulmonary diseaseAcetylcysteinePulmonary functionHigh-sensitivity C-reactive proteinProcalcitonin
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1016-1020 )