Effect of penehyclidine hydrochloride on pulmonary shunt, arterial oxygenation and pulmonary ventilation in patients undergoing radical resection of lung cancer
Fang Fang
Zhou Junhui
Liu Xiaole
Meng Rui
Xi Gaoyuan
Meng Xianhui
Abstract：Objective To investigate the effect of penehyclidine hydrochloride on pulmonary shunt,arterial oxygenation and pulmonary ventilation in patients undergoing radical surgery of lung cancer.Methods A total of 60 patients undergoing radical resection of lung cancer from March to November 2017 in Henan Provincial Chest Hospital were randomly divided into penehyclidine hydrochloride group (PHC group) and control group,with 30 patients in each group.The PHC group was intravenously injected penehyclidine hydrochloride 0.01 mg/kg and the control group was injected 0.9％ sodium chloride solution at 10 min before anesthesia induction.Hemodynamic indexes,blood gas indexes,intrapulmonary flow (QS/QT),alveolar-arterial oxygen partial pressure difference [P(A-a) DO2] and respiratory index were recorded before anesthesia induction(T0),before one-lung ventilation (T1),10 min(T2),30 min(T3),60 min(T4),120 min(T5) after one-lung ventilation,10 min after the end of one-lung ventilation (T6) and at the end of operation (T7).One-lung ventilation time,operation time and occurrence of mental abnormality during anesthesia recovery period were recorded.Results There were no significant differences of one-lung ventilation time,operation time,mean arterial pressure,heart rate,pulse oxygen saturation and airway pressure between groups (P ＞ 0.05).During T2-T5,arterial oxygen partial pressure in PHC group was significantly higher than that in control group;QS/QT,P(A-a) DO2 and respiratory index in PHC group were significantly lower than those in control group [Qs/QT:(31.4 ± 1.8) ％ vs (37.8 ± 2.7) ％,(26.5 ± 2.8) ％ vs (33.5±3.1)％,(22.9±1.9)％ vs (30.2±2.7)％,(18.9±2.6)％ vs (27.7±3.1)％;P(A-a) DO2:(433 ±40)mmHg vs (484 ±35)mmHg,(423 ±42)mmHg vs (467 ±36)mmHg,(386 ±42)mmHg vs (443 ± 37) mmHg,(332 ± 40) mmHg vs (405 ± 37) mmHg;respiratory index:(1.82 ± 0.26) vs (2.59 ± 0.32),(1.71 ±0.34) vs (2.29±0.31),(1.35±0.25) vs (1.96±0.26),(0.98±0.22) vs (1.53 ±0.29)](P＜ 0.05).No abnormal mental symptom was observed.Conclusion Intravenous administration of penehyclidine hydrochloride can effectively decrease intrapulmonary shunt,improve arterial oxygenation and pulmonary ventilation function in patients with radical resection of lung cancer.
Keywords：Radical resection of lung cancerPenehyclidine hydrochlorideOne-lung ventilationPulmonary shuntArterial oxygenationPulmonary ventilation
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1007-1011 )