Effect of intensity-modulated radiation therapy and volumetric intensity-modulated arc therapy on small cell lung cancer with superior vena cava syndrome
Ma Can
Fan Yimeng
Wu Yadong
Zhang Yan
Wang Peipei
Liu Ci
Zhang Yajing
Chen Xiaofang
Ma Zhiqian
Li Binghui
Guo Yan
Abstract：Objective To observe the effect of intensity-modulated radiation therapy (IMRT) and volumetric intensity-modulated arc therapy (VMAT) on small cell lung cancer with superior vena cava syndrome (SCVS).Methods Clinical records of 48 cases of small cell lung cancer with SCVS in the First Hospital of Shijiazhuang from January 2010 to January 2016 were reviewed;23 patients were treated with IMRT and 25 patients were treated with VMAT.Short-term curative effect of radiotherapy and survival condition of patients were analyzed.Results Symptom remission rates in IMRT group and VMAT group were 91.3％ (21/23) and 92.0％ (23/25) (P =0.548).Effective rates of radiotherapy in IMRT group and VMAT group were 82.6％ (19/23) and 84.0％ (21/25) (P =0.600).Local control rates in IMRT group and VMAT group were 69.6％ (16/23) and 84.0％ (21/25) (P=0.199).The 6-month,1-and 2-year survival rates in IMRT group and VMAT group were 69.2％ vs 72.0％,21.7％ vs32.0％,4.3％ vs8.0％(P=0.881,0.612,0.648).Conclusions Short-term therapeutic effects of IMRT and VMAT show no significant differences on small cell lung cancer patients with SCVC.VMAT shows a higher local control effect.
Keywords：Small cell lung cancerSuperior vena cava syndromeIntensity-modulated radiation therapyVolumetric intensity-modulated arc therapy
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1003-1006 )