Predictive effect of hemodynamic changes on capillary leakage syndrome after radical operation of tetralogy of fallot
Chen Zhe
Zhang Tingzhou
Yang Xueyong
Jing Xiaoyong
Liu Yinglong
Abstract：Objective To observe the hemodynamic changes in children after radical operation of tetralogy of fallot and to discuss the occurrence of capillary leakage syndrome.Methods Forty-four children undergoing radical operation of tetralogy of fallot from December 2016 to December 2017 in Beijing Anzhen Hospital,Capital Medical University were enrolled;capillary leakage syndrome occurred in 22 children after operation (leakage group) and 22 children did not have postoperative complication (no-leakage group).Hemodynamic parameters were recorded after incision(T0),after pericardium cut(T1),after removal of aortic cannula(T2) and at the end of operation(T3) using the Mostcare monitor.Hemodynamic factors related to capillary leakage syndrome were analyzed to obtain the forecasting equation.Results Aortic cross-clamp time and cardiopulmonary bypass time in leakage group were significantly longer than those in no-leakage group [(70 ± 15)min vs (62 ± 10)min,(96 ± 15)min vs (86 ± 11)min] (P ＜ 0.05).Diastolic pressure at T2,systemic vascular resistance at T3 and stroke output at T2 in leakage group were significantly higher than those in no-leakage group;left ventricular end-systolic elasticity at T3,left ventricular-artery coupling at T2 and T3 in leakage group were significantly lower than those in no-leakage group (all P ＜ 0.05).Logistic regression analysis showed that cardiopulmonary bypass time (x1),diastolic pressure (T2) (x2) and stroke output (T2) (x3) were sensitive predictors of capillary leakage syndrome;the predictive equation was P =1/[1 + e-(-15437+0.075x1 +0.085x2+0.483x3)];the predictive accuracy of the equation was 77.3％.Conclusion Hemodynamic parameters show good value in prediction of postoperative capillary leakage syndrome in children with radical operation of tetralogy of fallot.
Keywords：Tetralogy of fallotCapillary leakage syndromeHemodynamics
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 995-998 )