Correlation between plasma proprotein convertase subtilisin/kexin type 9 and tissue factor in patients with coronary heart disease
Wang Mei
Li Yanfang
Guo Yanqing
Chen Mengmeng
Jiang Zhili
Song Junying
Abstract：Objective To investigate the relation between plasma proprotein convertase subtilisin/kexin type 9(PCSK9) and tissue factor (TF) in patients with coronary artery disease (CAD).Methods A total of 210 patients with chest pain who visited Beijing Anzhen Hospital,Capital Medical University from July 2013 to March 2014 were enrolled;all patients have not been treated with statins and other types of lipid-lowering agents.They were divided into CAD group (n =120) and control group (without CAD) (n =90) based on coronary angiography results;patients in CAD group were divided into acute coronary syndrome(ACS) group(n =31) and stable CAD (SCAD) group (n =89).Plasma levels of PCSK9 and TF were tested and the correlation between them was analyzed.Risk factors of CAD were analyzed by logistic regression.Results Ratios of smoking history and diabetes history in CAD group were significantly higher than those in control group [62.5％ (75/120) vs 52.2％ (47/90),30.8％ (37/120) vs 16.7％ (15/90)];levels of low-density lipoprotein cholesterol (LDL-C) and PCSK9 in CAD group were significantly higher than those in control group [(3.0 ± 1.2) mmol/L vs (2.7 ± 0.9) mmol/L,(0.29 ± 0.08) mg/L vs (0.15 ± 0.04) mg/L];high-density lipoprotein cholesterol (HDL-C) level in CAD group was significantly lower than that in control group[(1.03 ±0.25) mmol/L vs(1.13 ±0.26) mmol/L] (all P ＜ 0.05).Logistic regression analysis showed that advanced age,smoking history,diabetes history,LDL-C,HDL-C,apolipoprotein-B,apolipoprotein-a,total cholesterol and PCSK9 were independent risk factors of CAD (P ＜ 0.05).TF level showed no significant difference between CAD group and control group(P ＞ 0.05).TF level in ACS group was significantly higher than that in SCAD group[(129 ±23) ng/L vs(116 ± 20) ng/L] (P ＜0.05).In ACS group,PCSK9 level was positively correlated with TF level (r =0.509,P =0.001).Conclusions PCSK9 is an independent risk factor of CAD and it is closely related with occurrence and development of atherosclerosis.Plasma PCSK9 level is positively correlated with TF level in ACS patients,suggesting that PCSK9 and TF may be involved in atherosclerotic plaque rupture.
Keywords：Coronary heart diseaseProprotein convertase subtilisin/kexin type 9Tissue factor
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 982-985 )