Significance of hyperuricemia in progression of renal artery disease in patients with hypertension

Zheng Bin; Liu Ruifang; Lin Ran; Liu Jinghua

doi:10.3760/j.issn.1673-4777.2018.07.005

Abstract：Objective To investigate the significance of hyperuricemia in progression of renal artery disease in patients with hypertension.Methods Clinical data of 159 hospitalized patients with hypertension in Beijing Anzhen Hospital,Capital Medical University from December 2003 to March 2014 were retrospectively analyzed.Related factors of progression of renal artery disease and renal insufficiency were analyzed.Results During 50(24,71) months of follow-up,23 patients had renal artery disease progression.Cox proportional hazards model analysis showed that renal artery stenosis [odds ratio (OR) =4.359,95％ confidence interval (CI):1.436-13.237,P =0.009] and hyperuricemia(OR =4.369,95％ CI:1.370-13.935,P =0.013) were predictors of renal artery disease progression.The 10-year cumulative incidence of renal artery disease progression was 27.3％ in patients without hyperuricemia and 71.6％ in patients with hyperuricemia;it was 31.2％ in patients without renal artery stenosis and 71.7％ in patients with renal artery stenosis.There were 36 patients having renal insufficiency progression.Cox proportional hazards model analysis showed that hyperuricemia was an predictive factor of renal insufficiency progression(OR =2.603,95％ CI:1.058-6.404,P =0.037).Renal artery disease progression was significantly associated with renal insufficiency progression(r =0.169,P =0.036).Conclusions Hyperuricemia is associated with progression of renal artery atherosclerotic disease.Progression of renal artery atherosclerotic disease is associated with progression of renal insufficiency.