Relation between homocysteine, C-reactive protein level and prognosis of percutaneous coronary intervention in patients with coronary atherosclerotic heart disease
Cao Jiandong
Ma Xiaofeng
Deng Yong
Wang Hong
Abstract：Objective To investigate the relation between homocysteine(Hcy),C-reactive protein(CRP) level and prognosis of percutaneous coronary intervention in patients with coronary atherosclerotic heart disease (CHD).Methods A total of 200 CHD patients undergoing PCI from October 2016 to October 2017 in Qinghai Cardio-Cerebrovascular Disease Hospital were enrolled;they were divided into normal Hcy level group (n =65) and Hcy increasing group(n =135);patients in Hcy increasing group were divided into CRP increasing group (＞3 mg/L,n=71) and normal CRP group(≤3 mg/L,n =64).Occurrences of major adverse cardiovascular events(MACE) were observed during hospitalization and follow-up period.Relation between Hcy,CRP level and MACE risk was analyzed by logistic regression.Results During hospitalization and follow-up period,incidence of MACE in Hcy increasing group was significantly lower than that in normal Hcy level group [1.5％ (1/65) vs 10.4％ (14/135),13.8％ (9/65) vs 27.4％ (37/135)];incidence of MACE in CRP increasing group was significantly lower than that in normal CRP normal group [4.7％ (3/64) vs 15.5％ (11/71),18.7％ (12/64) vs 35.2％ (25/71)] (all P ＜ 0.05).Hcy level increasing alone (OR =4.488,95％ CI:1.788-12.473,P =0.021),both Hcy and CRP level increasing(OR =12.537,95％ CI:8.563-31.435,P =0.005) were positively correlated with MACE risk after PCI.Conclusion Hcy and CRP detection has important guiding significance for evaluating the prognosis of CHD patients after PCI.
Keywords：Coronary heart diseasePercutaneous coronary interventionPrognosisHomocysteineC-reactive protein
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 973-976 )