Expression and significance of transforming growth factor β type Ⅱ recepter and Smad4 in pancreatic cancer
Feng Xiaojie
Chen Xue
Zhang Jie
Li Xue
Zhao Hongying
He Qiang
Fan Hua
Abstract：Objective To explore the expression and significance of transforming growth factor β type Ⅱ recepter (TβR Ⅱ),Smad4 in pancreatic cancer.Methods Expressions of TβR Ⅱ and Smad4 in 52 pancreatic cancer samples and 18 adjacent normal pancreatic samples were detected by immunohistochemistry.Correlations among expressions of TβR Ⅱ and Smad4,pathological features of pancreatic cancer and survival time of patients were analyzed.Results Positive expression rate of TβR Ⅱ in pancreatic cancer tissue was significantly higher than that in normal pancreatic tissue [55.8％ (29/52) vs 26.9％ (14/52),x2 =-8.921,P =0.003].Positive expression rate of Smad4 in pancreatic cancer tissue was significantly lower than that in normal pancreatic tissue [48.1％ (25/52) vs 92.3 ％ (48/52),x2 =24.31,P ＜ 0.001].Expression of TβR Ⅱ was related to the TNM classification of pancreatic cancer(x2 =6.195,P =0.045).Median survival time of patients with positive Smad4 expression was significantly longer than that of patients with negative Smad4 expression (12.1 months vs 7.9 months,Log-Rank =14.622,P ＜ 0.001).Conclusion Patients with negative Smad4 expression are associated with shorter survival period and poor prognosis of pancreatic cancer;there is a correlation between Smad4 expression and TβR Ⅱ expression.
Keywords：Pancreatic neoplasmsTransforming growth factor β type Ⅱ recepterSmad4Immunohistochemistry
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 886-890 )