Significances of hepatitis C virus RNA and liver function indicators in diagnosis of heptitis C

Li Juan; Liu Yiqing; Zhang Yue; Yu Miao; Dong Zhenfang; Fan Gang; Wang Changyin; Lu Zhiming; Zhang Bingchang

doi:10.3760/j.issn.1673-4777.2018.06.021

Abstract：Objective To explore the clinical significances of hypersensitive hepatitis C virus(HS-HCV)RNA and liver function indicators in diagnosis of heptitis C.Methods Totally 904 patients with hepatitis C were enrolled from January 2016 to June 2017 in Shandong Provincial Hospital Affiliated to Shandong University.HS-HCV RNA was detected by the real-time fluorescent quantitative polymerase chain reaction.Levels of total bilirubin (TBIL),direct bilirubin (DBIL),aspartate aminotransferase (AST),alanine aminotransferase (ALT) and α-L-fucosidase(AFU) were detected by the automatic biochemical analyzer.Values of liver function indicators in diagnosis of heptitis C were analyzed by the receiver operating characteristic(ROC) curve.Results Positive rate of HS-HCV RNA in female patients was significantly higher than that in male patients [53.4％ (230/431) vs 43.3％ (205/473)] (x2 =9.076,P ＜ 0.05).Abnormal rates of TBIL,DBIL,AST,ALT and AFU showed significant differences among groups with different HS-HCV RNA (P ＜ 0.01).Abnormal rate of AST was the highest in hepatitis C patients(40.3％).Area under curve of AST in diagnosis of heptitis C was 0.765;area under curve of combined detection of 5 liver function indicators was 0.853.The sensitivity of AST(74.8％) and the specificity of ALT(79.7％) was the highest in diagnosis of heptitis C;combined detection showed higher sensitivity (77.8％)and specificity(78.0％).Conclusions HS-HCV RNA can reflect virus replication and course of hepatitis C;it is associated the levels of liver function indicators.HS-HCV RNA and liver function indicators have good diagnostic values for hepatitis C.