Effect of Tianmeng oral liquid combined with atypical antipsychotic drugs on serum prolactin and sex hormone in patients with schizophrenia
Wang Qian
Bai Ludong
Zhang Ming
Fan Liqiang
Li Xiaoqing
Abstract：Objective To investigate the effect of Tianmeng oral liquid combined with atypical antipsychotic drugs on serum prolactin and sex hormone in patients with schizophrenia.Methods Totally 240 patients with schizophrenia admitted in Shandong Mental Health Center from February 2014 to August 2017 were randomly divided into 6 groups (n =40) taking risperidone,aripiprazole,quetiapine,risperidone combined with Tianmeng oral liquid,aripiprazole combined with Tianmeng oral liquid,quetiapine combined with Tianmeng oral liquid,respectively.Levels of serum prolactin,testosterone and estradiol were analyzed 8 weeks after treatment.Results After treatment,levels of serum prolactin in risperidone group,aripiprazole group and quetiapine group significantly increased compared to those before treatment [(16 ± 9) μg/L vs (10 ± 6) μg/L,(16 ± 7) μg/L vs (11 ±4) μg/L,(16 ±6) μg/L vs (10 ±5) μg/L];level of serum testosterone significantly decreased in males and increased in females compared to those before treatment[males:(15 ± 8) pmol/L vs (21 ± 9) pmol/L,(16 ±5)pmol/L vs (20 ± 8)pmol/L,(16 ±5)pmol/L vs (20 ± 8) pmol/L;females:(2.4 ±0.8)pmol/L vs (1.6 ±0.8) pmol/L,(2.3 ± 0.6) pmol/L vs (1.7 ± 0.8) pmol/L,(2.2 ± 0.5) pmol/L vs (1.6 ± 0.8) pmol/L];level of serum estradiol significantly increased in males and decreased in females compared to those before treatment [males:(138 ±49)pmol/L vs (108 ±43)pmol/L,(131 ±35)pmol/L vs (108 ±43)pmol/L,(130 ±32)pmol/L vs (108 ±43)pmol/L;females:(131 ± 88) pmol/L vs (300 ± 120) pmol/L,(155 ± 82)pmol/L vs (300 ± 119)pmol/L,(161 ± 96) pmol/L vs (302 ± 121) pmol/L] (all P ＜ 0.05).Levels of serum prolactin,testosterone and estradiol showed no significant differences before and after treatment in risperidone combined with Tianmeng oral liquid group,aripiprazole combined with Tianmeng oral liquid group and quetiapine combined with Tianmeng oral liquid group(all P ＞ 0.05).Conclusion Tianmeng oral liquid combined with atypical antipsychotic drugs treating schizophrenia can reduce the adverse effect of atypical antipsychotic drugs on serum prolactin and sex hormone.
Keywords：SchizophreniaAtypical antipsychotic drugsTianmeng oral liquidSex hormoneProlactin
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 870-874 )