Effect of buspirone hydrochloride tablets combined with risperidone tablets on negative symptoms of stable schizophrenia
Qin Qiuhong
Jiang Tao
Abstract：Objective To observe the effect of buspirone hydrochloride tablets combined with risperidone tablets on negative symptoms of stable schizophrenia.Methods A total of 60 patients with schizophrenia of stable phase in BeiJing Huairou Anjia Hospital from January 2014 to January 2016 were randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with buspirone hydrochloride tablets;the observation group was treated with buspirone hydrochloride tablets combined with risperidone tablets.The Positive and Negative Symptom Scale (PANSS) was used to evaluate the therapeutic effect;the Trcatment Emergent Symptom Scale was used to evaluate adverse reactions.Results The PANSS score showed no significant difference between groups before treatment and 4 weeks after treatment(P ＞ 0.05).Eight weeks after treatment,the negative symptom score in observation group was significantly lower than that before treatment and 4 weeks after treatment;the negative symptom score in observation group was significantly lower than that in control group [(15±4) vs (18±5),(17±4),(18±5)](P＜0.05).There was no significant difference of incidence of adverse reactions between groups (P ＞ 0.05).Conclusion Risperidone combined with buspirone hydrochloride is safe and effective in treatment of the negative symptoms of stable schizophrenia.
Keywords：SchizophreniaBuspirone hydrochlorideRisperidoneNegative symptomsStable phase
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 866-869 )