Effects of different lipid-lowering treatments on coronary atherosclerotic heart disease patients with statin intolerance
Han Jing
Wang Songtao
Nie Shaoping
Duan Xiaochun
Abstract：Objective To analyze the lipid-lowering effects of ezetimibe and atorvastatin on coronary atherosclerotic heart disease(CHD) patients with statin intolerance.Methods Totally 121 CHD patients intolerant to statins from January 2014 to June 2017 in Beijing Anzhen Hospital,Capital Medical University and Armed Police Beijing Corps Hospital were randomly divided into ezetimibe group(10 mg/d,n =40),atorvastain group (10 mg,twice a week,n =41) and combination group(ezetimibe combined with atorvastain,n =40).Changes of blood lipid indicators and occurrence of adverse drug reactions were analyzed after 12 weeks of treatment.Results Levels of triacylglycerol (TG),total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C)after treatment were significantly lower than those before treatment in ezetimibe group and combination group [ezetimibe group:(1.4 ± 0.4) mmol/L vs (2.2 ± 0.6) mmol/L,(4.2 ± 0.7) mmol/L vs (5.2 ± 0.9) mmol/L,(3.2 ± 0.6) mmol/L vs(3.9 ± 0.7) mmol/L;combination group:(1.4 ± 0.4) mmol/L vs (2.2 ± 0.6) mmol/L,(3.8 ±0.6)mmol/L vs(5.2 ±0.8)mmol/L,(2.8 ±0.5)mmol/L vs(3.9 ±0.7)mmol/L] (P ＜0.05).Levels of TC and LDL-C after treatment were significantly lower than those before treatment in atorvastain group[(4.2 ±0.8)mmol/L vs(5.3 ±0.7)mmol/L,(3.1 ±0.6)mmol/L vs(3.9±0.7)mmol/L] (P＜0.05).After treatment,levels of TC and LDL-C in combination group were significantly lower than those in ezetimibe group;levels of TC,TG and LDL-C in combination group were significantly lower than those in atorvastain group (P ＜0.05).After 12 weeks of treatment,rate of LDL-C level reaching the standard in combination group was significantly higher than that in ezetimibe group and atorvastain group[22.5％ (9/40) vs 2.5％ (1/40),2.4％ (1/41)] (P ＜0.05).There was no severe adverse reaction during treatment.Conclusion Ezetimibe combined with atorvastatin treating CHD patients with statin intolerance can effectively improve the lipid-lowering effect.
Keywords：Coronary heart diseaseStatin intoleranceAtorvastainEzetimibe
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 801-804 )