Effect of theophylline sustained-release tablets combined with salmeterol xinafoate and fluticasone propionate inhalation on chronic obstructive pulmonary disease and quality of life

Zhao Bo; Liu Feng; Zou Xiaoguang

doi:10.3760/j.issn.1673-4777.2018.05.017

Abstract：Objective To explore the effect of theophylline sustained-release tablets combined with salmeterol xinafoate and fluticasone propionate inhalation on chronic obstructive pulmonary disease (COPD) and quality of life.Methods Totally 74 patients with COPD from July 2016 to May 2017 in the First People's Hospital of Kashi were randomly divided into observation group and control group,with 37 cases in each group.The control group was treated with salmeterol xinafoate and fluticasone propionate inhalation;the observation group was treated with theophylline sustained-release tablets combined with salmeterol xinafoate and fluticasone propionate inhalation;both groups were treated for 3 months.Six minutes walk distance(6MWD),scores of the COPD Assessment Test (CAT) and the St George's Respiratory Questionnaire (SGRQ),forced expiratory volume in 1 second to forced vital capacity ratio(FEV1/FVC),percentage of FEV1 in the predicted value (FEV1 ％),inspiratory capacit (IC) and adverse reactions were analyzed.Results After treatment,6MWD,FEV1/FVC,FEV1 ％ and IC in observation group were significantly longer/higher than those in control group[(326 ± 14)m vs (306 ± 17)m,(61 ±9)％ vs (56 ± 10) ％,(49 ± 9) ％ vs (44 ± 9) ％,(2.1 ± 0.4) L vs (1.8 ± 0.4) L];CAT score and SGRQ score (disease symptom score,activity of daily living score,disease impact score and total score) in observation group were significantly lower than those in control group [(20.6 ± 1.1) vs (23.5 ± 1.2),(41 ± 12) vs (47 ± 12),(45±10)vs(53 ±10),(38±10)vs(43 ±10),(41 ±10)vs(47±11)](P＜0.05).Incidence of adverse reactions showed no significant difference between groups (P ＞ 0.05).Conclusion Theophylline sustained-release tablets combined with salmeterol xinafoate and fluticasone propionate inhalation has a good therapeutic effect on COPD;it can effectively improve lung function and quality of life.